期刊
CEREBROVASCULAR DISEASES
卷 29, 期 1, 页码 79-81出版社
KARGER
DOI: 10.1159/000256651
关键词
Acute-stroke therapy; Acute treatment; Thrombolysis; Antiplatelet therapy; Randomized controlled trials; Aspirin
资金
- Netherlands Heart Foundation [2005B118]
Background: Thrombolysis with recombinant tissue plasminogen activator (rt-PA) is currently the only approved acute therapy for ischemic stroke. After rt-PA-induced recanalization, reocclusion is observed in 20-34%, probably caused by platelet activation. In acute myocardial infarction, the combination of thrombolytic and antiplatelet therapy leads to a better outcome compared to thrombolytic treatment alone. In patients with acute ischemic stroke, several studies showed that those on antiplatelet treatment prior to rt-PA had an equal or even better outcome compared to patients without prior use of antiplatelet therapy, despite an increased risk of bleeding. Methods: We present the protocol of a multicenter randomized clinical trial (n = 800) investigating the effects of immediate addition of aspirin to rt-PA on poor outcome (modified Rankin score > 2) in ischemic stroke patients. Conclusion: This study will answer the question whether the combination of rt-PA and antiplatelet therapy improves the functional outcome in ischemic stroke patients. Copyright (C) 2009 S. Karger AG, Basel
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