期刊
ULTRASOUND IN MEDICINE AND BIOLOGY
卷 27, 期 1, 页码 33-42出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/S0301-5629(00)00279-9
关键词
high-intensity focused ultrasound; real-time image guidance; visualization; therapy; targeting; monitoring
资金
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL064208] Funding Source: NIH RePORTER
- NHLBI NIH HHS [1RO1HL64208] Funding Source: Medline
High-intensity focused ultrasound (HIFU) and conventional B-mode ultrasound (US) imaging were synchronized to develop a system for real-time visualization of HIFU treatment. The system was tested in vivo in pig liver. The HIFU application resulted in the appearance of a hyperechoic spot at the focus that faded gradually after cessation of HIFU exposure. The duration of HIFU exposure needed for a hyperechoic spot to appear, was inversely related to the HIFU intensity. The threshold intensity required to produce a hyperechoic spot in liver in < is was 970 W/cm(2), in situ. At this HIFU dose, no immediate cellular damage was observed, providing a potential for pretreatment targeting. The real-time visualization method was used in hemostasis of actively bleeding internal pelvic vessels, allowing targeting and monitoring of successful treatment. Real-time US imaging may provide a useful tool for image-guided HIFU therapy. CE-mail: adasi@u.washington.edu) (C) 2001 World Federation for Ultrasound in Medicine & Biology.
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