期刊
CEREBRAL CORTEX
卷 24, 期 10, 页码 2604-2618出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/cercor/bht114
关键词
Cajal-Retzius cells; interneurons; layer 1; neocortex
资金
- Natural Science Foundation of China [31070947, 31121061, 31271157]
- Ministry of Science and Technology of China [2012CB 966300]
- Pujiang Talent Project of the Shanghai Science and Technology Committee [10PJ1400700]
- Innovation Program of Shanghai Municipal Education Commission [12ZZ007]
- Foundation of Ministry of Education of China [20100071120061]
Layer 1 of the neocortex harbors a unique group of neurons that play crucial roles in synaptic integration and information processing. Although extensive studies have characterized the properties of layer 1 neurons in the mature neocortex, it remains unclear how these neurons progressively acquire their distinct morphological, neurochemical, and physiological traits. In this study, we systematically examined the dynamic development of Cajal-Retzius cells and gamma-aminobutyric acid (GABA)-ergic interneurons in layer 1 during the first 2 postnatal weeks. Cajal-Retzius cells underwent morphological degeneration after birth and gradually disappeared from layer 1. The majority of GABAergic interneurons showed clear expression of at least 1 of the 6 distinct neurochemical markers, including Reelin, GABA-A receptor subunit delta (GABA(A)R delta), neuropeptide Y, vasoactive intestinal peptide (VIP), calretinin, and somatostatin from postnatal day 8. Furthermore, according to firing pattern, layer 1 interneurons can be divided into 2 groups: late-spiking (LS) and burst-spiking (BS) neurons. LS neurons preferentially expressed GABA(A)R delta, whereas BS neurons preferentially expressed VIP. Interestingly, both LS and BS neurons exhibited a rapid electrophysiological and morphological development during the first postnatal week. Our results provide new insights into the molecular, morphological, and functional developments of the neurons in layer 1 of the neocortex.
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