期刊
TRENDS IN CELL BIOLOGY
卷 11, 期 1, 页码 6-10出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/S0962-8924(00)01874-2
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Apoptosis, molecularly regulated cell death,can be induced by a range of environmental, physical or chemical stresses,and is characterized by a sequence of precisely regulated events that culminate in the self-destruction of a cell. Fascinating biochemical and genetic parallels exist between the cell death pathways of different animal species. However, an even more highly conserved and evolutionarily ancient cellular response can be engaged as a consequence of stress, which functions to maintain cellular survival. This response is mediated by the heat-shock or stress proteins. This article discusses the functional interactions between the stress response and the apoptotic cell death pathway and how these might impact on determining cellular survival.
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