期刊
CEREBRAL CORTEX
卷 24, 期 10, 页码 2669-2678出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/cercor/bht121
关键词
cortex; magnetoencephalography; MEG; motor control; oscillations
资金
- Michael J. Fox Foundation for Parkinson's Research
- Francine and Louis Blumkin Foundation
- Community Neuroscience Pride of Nebraska Research Initiative
- Carol Swarts, M.D., Laboratory of Emerging Neuroscience Research
- Alan Baer Charitable Trust
- Schumacher Foundation
- National Institutes of Health [P20 DA026146, 5P01 DA028555-02, R01 NS36126, P01 NS31492, 2R01 NS034239, P20 RR15635, P01 MH64570, P01 NS43985, R01 NS070190]
- Hattie B. Munroe Foundation
- University of Nebraska Medical Center Research Development Funds
Parkinson's disease (PD) is a neurodegenerative disorder associated with debilitating motor, posture, and gait abnormalities. Human studies recording local field potentials within the subthalamic nucleus and scalp-based electroencephalography have shown pathological beta synchronization throughout the cortical-basal ganglia motor network in PD. Suppression of such pathological beta synchronization has been associated with improved motor function, which may explain the effectiveness of deep-brain stimulation. We used magnetoencephalography (MEG) to investigate neural population-level beta responses, and other oscillatory activity, during a motor task in unmedicated patients with PD and a matched group of healthy adults. MEG is a noninvasive neurophysiological technique that permits the recording of oscillatory activity during movement planning, execution, and termination phases. Each of these phases was independently examined using beamforming to distinguish the brain areas and movement phases, where pathological oscillations exist during motor control. Patients with PD exhibited significantly diminished beta desynchronization compared with controls prior to and during movement, which paralleled reduced alpha desynchronization. This study is the first to systematically investigate neural oscillatory responses in PD during distinct stages of motor control (e. g. planning, execution, and termination) and indicates that these patients have significant difficulty suppressing cortical beta synchronization during movement planning, which may contribute to their diminished movement capacities.
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