期刊
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
卷 21, 期 1, 页码 2-14出版社
SAGE PUBLICATIONS INC
DOI: 10.1097/00004647-200101000-00002
关键词
reactive oxygen species; free radicals; apoptosis; cerebral ischemia; transgenic and knockout mice; oxidative stress signaling
资金
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [P50NS014543, R01NS036147, P01NS014543, R01NS025372] Funding Source: NIH RePORTER
- NINDS NIH HHS [NS25372, NS14543, NS36147] Funding Source: Medline
Reactive oxygen species have been implicated in brain injury after ischemic stroke. These oxidants can react and damage the cellular macromolecules by virtue of the reactivity that leads to cell injury and necrosis. Oxidants an also media- tors in signaling involving mitnchondria, DNA repair enzymes, and transcription factors that may lead to apoptosis after cerebral ischemia. Transgenic or knockout mice with cell- or site-specific prooxidant and antioxidant enzymes provide useful tools in dissecting the events involving oxidative stress in signaling and damage in ischemic brain injury.
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