期刊
FREE RADICAL RESEARCH
卷 34, 期 4, 页码 395-404出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/10715760100300331
关键词
retinol; oxidative stress; reactive oxygen species; lipid peroxidation; catalase; glutathione peroxidase; superoxide dismutase
Recent intervention studies revealed that supplementation with retinoids resulted in a higher incidence of lung cancer. Recently the causal mechanism has begun to be clarified. We report here that retinol caused cellular oxidative stress and modulated superoxide dismutase, catalase and glutathione peroxidase activities. Retinol (7 muM) significantly increased TBARS, conjugated dienes, and hydroperoxide-initiated chemiluminescence in cultured Sertoli cells. In response to retinol treatment superoxide dismutase, catalase and glutathione peroxidase activities increased. TBARS content and catalase activities were decreased by a free radical scavenger. These findings suggest that retinol may induce oxidative stress and modulate antioxidant enzyme activities in Sertoli cells.
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