期刊
CEREBRAL CORTEX
卷 24, 期 11, 页码 2899-2907出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/cercor/bht146
关键词
fMRI; perception; top-down
资金
- National Institutes of Health [DP1OD003312]
- National Institute of Mental Health [K01MH084011]
- National Eye Institute [NEI 1R01EY019477-01]
- Defense Advanced Research Projects Agency [N10AP20036]
- National Science Foundation [NSF BCS-0842947]
Predicting upcoming events from incomplete information is an essential brain function. The orbitofrontal cortex (OFC) plays a critical role in this process by facilitating recognition of sensory inputs via predictive feedback to sensory cortices. In the visual domain, the OFC is engaged by low spatial frequency (LSF) and magnocellular-biased inputs, but beyond this, we know little about the information content required to activate it. Is the OFC automatically engaged to analyze any LSF information for meaning? Or is it engaged only when LSF information matches preexisting memory associations? We tested these hypotheses and show that only LSF information that could be linked to memory associations engages the OFC. Specifically, LSF stimuli activated the OFC in 2 distinct medial and lateral regions only if they resembled known visual objects. More identifiable objects increased activity in the medial OFC, known for its function in affective responses. Furthermore, these objects also increased the connectivity of the lateral OFC with the ventral visual cortex, a crucial region for object identification. At the interface between sensory, memory, and affective processing, the OFC thus appears to be attuned to the associative content of visual information and to play a central role in visuo-affective prediction.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据