期刊
NEUROPSYCHOLOGIA
卷 39, 期 13, 页码 1419-1431出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0028-3932(01)00059-8
关键词
Alzheimer's disease; short-term memory; semantic process; Parkinson's disease
资金
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS035867] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [R01AG015116, P01AG017586] Funding Source: NIH RePORTER
- NIA NIH HHS [AG 17586, AG 15116] Funding Source: Medline
- NINDS NIH HHS [NS 35867] Funding Source: Medline
This study assessed sentence comprehension in Alzheimer's disease (AD) while minimizing executive resource demands. AD patients (n = 17) and healthy elderly control subjects (n = 17) were asked to detect a word in a sentence. Unbeknownst to subjects, the target word at times followed an incorrect grammatical or semantic agreement. Control subjects took significantly longer to respond to a target word when it immediately followed an agreement violation compared to a coherent agreement, a difference that was not evident when the target word followed the agreement by several syllables. AD patients did not demonstrate a discrepancy between a violation and a coherent agreement in the immediate vicinity of the agreement, but demonstrated a significant delay in their response to a target word when it followed an agreement violation - particularly a violation of a grammatical agreement - by several syllables. Analyses of individual patient performance profiles revealed the pattern of delayed sensitivity to agreements in a majority of AD patients. Correlation and regression analyses associated AD patients' sensitivity to agreement violations over an abnormally delayed time course with a measure of inhibitory control, although weaker associations were also evident with measures of planning and short-term memory. We hypothesize that difficulty understanding grammatically complex sentences in AD is related to slowed information processing speed that restricts the timely construction of a sentence's structure and limits inhibition of canonical sentence interpretations such as first-noun-is-subject. (C) 2001 Elsevier Science Ltd. All rights reserved.
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