期刊
PATHOLOGY RESEARCH AND PRACTICE
卷 197, 期 12, 页码 803-809出版社
URBAN & FISCHER VERLAG
DOI: 10.1078/0344-0338-00163
关键词
atherosclerosis; carotid artery; morphometry; atherometric system
类别
The carotid artery bifurcation is of special interest to both the pathologist because Of its frequent atherosclerotic depositions, and to the fluidmechanicist because of its complex flow properties. However, current knowledge is incomplete regarding the level and position of atherosclerotic plaques in the carotid bifurcation and their quantitative correlation with its geometry. The study presented here is intended to fill that knowledge gap and try to quantify the geometrical risk factors. During the post-mortem the arteries were excised and filled with a resin at the proper transmural pressure of 80 mm Hg. Thirty-one vessel casts of the carotid artery from twenty-three autopsied individuals were made. The vessel casts were used to measure several geometrical parameters. After fabrication of the vessel casts each artery was investigated according to pathomorphological procedure, Ail atherometric system (AS) indicating the level of atherosclerotic lesions was applied. The specimens were divided into three groups according to the level of atherosclerosis. The comparison was made between the level of wall alteration of the main branches of the carotid bifurcation (common, internal and external carotid branch), and between these three groups themselves. Further, we conducted a comparison of the averaged geometric parameters in different groups to define the correlations between atherosclerotic lesions and geometric parameters. The results show that the most advanced lesions (Fibrous and severe plaques) with about 70% of all lesions were mainly found in the internal and the external carotid branches, compare with only 25% for the common carotid branch. The comparative analysis showed that a relatively high carotid sinus enlargement of > 1.2 of the common carotid branch diameter is a most significant geometric risk factor among those investigated, whereas there was no correlation between branch angles and atherosclerosis. In conclusion, the quantification of atherosclerotic risk factors is very important in the investigation of atherosclerotic disease development.
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