期刊
CEREBRAL CORTEX
卷 22, 期 10, 页码 2241-2262出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/cercor/bhr291
关键词
architectonic; areas; maps; registration; retinotopy
资金
- National Institute of Mental Health [R01 MH 60974]
- Human Connectome Project 16 National Institutes of Health (NIH) Institutes [1U54MH091657-01]
- McDonnell Center for Systems Neuroscience at Washington University
We report on surface-based analyses that enhance our understanding of human cortical organization, including its convolutions and its parcellation into many distinct areas. The surface area of human neocortex averages 973 cm(2) per hemisphere, based on cortical midthickness surfaces of 2 cohorts of subjects. We implemented a method to register individual subjects to a hybrid version of the FreeSurfer fsaverage atlas whose left and right hemispheres are in precise geographic correspondence. Cortical folding patterns in the resultant population-average fs_LR midthickness surfaces are remarkably similar in the left and right hemispheres, even in regions showing significant asymmetry in 3D position. Both hemispheres are equal in average surface area, but hotspots of surface area asymmetry are present in the Sylvian Fissure and elsewhere, together with a broad pattern of asymmetries that are significant though small in magnitude. Multiple cortical parcellation schemes registered to the human atlas provide valuable reference data sets for comparisons with other studies. Identified cortical areas vary in size by more than 2 orders of magnitude. The total number of human neocortical areas is estimated to be similar to 150 to 200 areas per hemisphere, which is modestly larger than a recent estimate for the macaque.
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