期刊
CEREBRAL CORTEX
卷 22, 期 2, 页码 363-371出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/cercor/bhr112
关键词
motor-evoked potential; primary motor cortex; response inhibition; stop signal task; subthalamic nucleus
资金
- Alfred P. Sloan Foundation
- National Institutes of Health National Institute on Drug Abuse [DA026452]
- National Science Foundation [0921168]
- Direct For Social, Behav & Economic Scie
- Division Of Behavioral and Cognitive Sci [0921168] Funding Source: National Science Foundation
Stopping an initiated response is an essential function, investigated in many studies with go/no-go and stop-signal paradigms. These standard tests require rapid action cancellation. This appears to be achieved by a suppression mechanism that has global effects on corticomotor excitability (i.e., affecting task-irrelevant muscles). By contrast, stopping action in everyday life may require selectivity (i.e., targeting a specific response tendency without affecting concurrent action). We hypothesized that while standard stopping engages global suppression, behaviorally selective stopping engages a selective suppression mechanism. Accordingly, we measured corticomotor excitability of the task-irrelevant leg using transcranial magnetic stimulation while subjects stopped the hand. Experiment 1 showed that for standard (i.e., nonselective) stopping, the task-irrelevant leg was suppressed. Experiment 2 showed that for behaviorally selective stopping, there was no mean leg suppression. Experiment 3 directly compared behaviorally nonselective and selective stopping. Leg suppression occurred only in the behaviorally nonselective condition. These results argue that global and selective suppression mechanisms are dissociable. Participants may use a global suppression mechanism when speed is stressed; however, they may recruit a more selective suppression mechanism when selective stopping is behaviorally necessary and preparatory information is available. We predict that different fronto-basal-ganglia pathways underpin these different suppression mechanisms.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据