4.6 Article

White Matter Aberrations in Prepubertal Estrogen-Naive Girls with Monosomic Turner Syndrome

期刊

CEREBRAL CORTEX
卷 22, 期 12, 页码 2761-2768

出版社

OXFORD UNIV PRESS INC
DOI: 10.1093/cercor/bhr355

关键词

diffusion tensor imaging (DTI); MRI; neuroimaging; turner syndrome; voxel-based morphometry (VBM)

资金

  1. National Institute of Health [5-R01-HD049653]
  2. Chain of Love Foundation
  3. American Psychiatric Institute for Research and Education/Lilly Psychiatric Research Fellowship Award
  4. National Institute of Mental Health [T32-MH19908]

向作者/读者索取更多资源

Turner syndrome (TS) offers a unique opportunity to investigate associations among genes, the brain, and cognitive phenotypes. In this study, we used 3 complementary analyses of diffusion tensor imaging (DTI) data (whole brain, region of interest, and fiber tractography) and a whole brain volumetric imaging technique to investigate white matter (WM) structure in prepubertal, nonmosaic, estrogen-naive girls with TS compared with age and sex matched typically developing controls. The TS group demonstrated significant WM aberrations in brain regions implicated in visuospatial abilities, face processing, and sensorimotor and social abilities compared with controls. Extensive spatial overlap between regions of aberrant WM structure (from DTI) and regions of aberrant WM volume were observed in TS. Our findings indicate that complete absence of an X chromosome in young females (prior to receiving exogenous estrogen) is associated with WM aberrations in specific regions implicated in characteristic cognitive features of TS.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.6
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据