期刊
CEREBRAL CORTEX
卷 22, 期 12, 页码 2820-2830出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/cercor/bhr359
关键词
caudal ganglionic eminence; fetal cerebral cortex; human cortical progenitors; interneurons
资金
- National Institutes of Health [2R01NS041489-10A1]
- National Society for Multiple Sclerosis [RG 3083-D-5]
Transcription factor COUP-TFII in rodents is important for migration of cortical interneurons from caudal ganglionic eminence (CGE) to the neocortex. Since in human, unlike in rodents, cortical interneurons have both ganglionic eminence (GE) and dorsal cortical origin, we studied the distribution of COUP-TFII in the human developing neocortex from 9 to 22 gestational weeks. COUP-TFII is expressed at all stages studied in the GE and in various cortical zones, from the proliferative ventricular/subventricular zone (VZ/SVZ) to layer I. Gradients of COUP-TFII expression are present in the GE, with peak expression in the CGE, and in the neocortex, from high expression in the temporal and occipital cortex to moderate in the frontal and dorsal cortex. Double immunofluorescence with gamma-aminobutyric acid (GABA), calretinin, or calbindin, established that subpopulations of interneurons express COUP-TFII. A small fraction of COUP-TFII+ cells are progenitor cells that proliferate in the CGE (3.4 +/- 0.3%) and in the cortical VZ/SVZ (1.7 +/- 0.1%). In summary, COUP-TFII is expressed in the human fetal forebrain in GABAergic cells, according to its possible role in migration of cortical interneurons. The source of these cells seems to be the CGE and, to a smaller extent, the cortical VZ/SVZ.
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