期刊
CEREBRAL CORTEX
卷 22, 期 11, 页码 2519-2528出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/cercor/bhr323
关键词
confocal imaging; dendritic spines; long-term plasticity; memory storage; structural plasticity
资金
- Israel Science Foundation
- Pratt Foundation
- US-Israel Binational Science Foundation [2007141]
- Div Of Information & Intelligent Systems
- Direct For Computer & Info Scie & Enginr [2007141] Funding Source: National Science Foundation
Protein kinase M zeta (PKM zeta), an atypical isoform of protein kinase C (PKC), has been implicated in long-term maintenance of neuronal plasticity and memory. However, the cellular machinery involved in these functions has yet to be elucidated. Here, we investigated the effects of PKM zeta overexpression on the morphology and function of cortical neurons in primary cultures. Transfection with a plasmid construct expressing the PKM zeta gene modified the distribution of spine morphologies and reduced spine length, while leaving total spine density and dendritic branching unchanged. A significant increase in magnitude but not frequency of miniature excitatory post synaptic currents was detected in the PKM zeta overexpressing cells. These results suggest that PKM zeta is involved in regulation of dendritic spine structure and function, which may underlie its role in long-term synaptic and behavioral plasticity.
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