期刊
CEREBRAL CORTEX
卷 21, 期 2, 页码 374-384出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/cercor/bhq105
关键词
burst-suppression anesthesia; functional MRI; hemodynamic fluctuation; neurovascular coupling; spontaneous brain activity
资金
- National Institutes of Health [NS041262, NS041262S1, EB000329, NS057560, P41 RR008079, P30NS057091]
- Keck Foundation
Spontaneous hemodynamic signals fluctuate coherently within many resting-brain functional networks not only in awake humans and lightly anesthetized primates but also in animals under deep anesthesia characterized by burst-suppression electroencephalogram (EEG) activity and unconsciousness. To understand the neural origin of spontaneous hemodynamic fluctuations under such a deep anesthesia state, epidural EEG and cerebral blood flow (CBF) were simultaneously recorded from the bilateral somatosensory cortical regions of rats with isoflurane-induced burst-suppression EEG activity. Strong neurovascular coupling was observed between spontaneous EEG bursts and CBF bumps, both of which were also highly synchronized across the 2 hemispheres. Functional magnetic resonance imaging (fMRI) was used to image spontaneous blood oxygen level-dependent (BOLD) signals under the same anesthesia conditions and showed similar BOLD bumps and dependence on anesthesia depth as the CBF signals. The spatiotemporal BOLD correlations indicate a strong but less-specific coherent network covering a wide range of cortical regions. The overall findings reveal that the spontaneous CBF/BOLD fluctuations under unconscious burst-suppression anesthesia conditions originate mainly from underlying neural activity. They provide insights into the neurophysiological basis for the use of BOLD- and CBF-based fMRI signals for noninvasively imaging spontaneous and synchronous brain activity under various brain states.
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