期刊
CEREBRAL CORTEX
卷 20, 期 11, 页码 2702-2711出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/cercor/bhq015
关键词
concurrent TMS-fMRI; posterior parietal cortex; state-dependence; visuospatial attention
资金
- Wellcome Trust
- Medical Research Council
- Federal Ministry of Education and Research (Bundesministerium fur Bildung und Forschung)
- Biotechnology and Biological Sciences Research Council
- EU [200728]
- Foundations of Human Social Behavior at the University of Zurich
- BBSRC [BB/F02424X/1] Funding Source: UKRI
- MRC [G0500784] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/F02424X/1] Funding Source: researchfish
- Medical Research Council [G0500784] Funding Source: researchfish
Combining transcranial magnetic stimulation (TMS) with concurrent functional magnetic resonance imaging (fMRI) allows study of how local brain stimulation may causally affect activity in remote brain regions. Here, we applied bursts of high- or low-intensity TMS over right posterior parietal cortex, during a task requiring sustained covert visuospatial attention to either the left or right hemifield, or in a neutral control condition, while recording blood oxygenation-level-dependent signal with a posterior MR surface coil. As expected, the active attention conditions activated components of the well-described attention network, as compared with the neutral baseline. Also as expected, when comparing left minus right attention, or vice versa, contralateral occipital visual cortex was activated. The critical new finding was that the impact of high- minus low-intensity parietal TMS upon these visual regions depended on the currently attended side. High- minus low-intensity parietal TMS increased the difference between contralateral versus ipsilateral attention in right extrastriate visual cortex. A related albeit less pronounced pattern was found for left extrastriate visual cortex. Our results confirm that right human parietal cortex can exert attention-dependent influences on occipital visual cortex and provide a proof of concept for the use of concurrent TMS-fMRI in studying how remote influences can vary in a purely top-down manner with attentional demands.
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