期刊
CEREBRAL CORTEX
卷 19, 期 9, 页码 2078-2091出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/cercor/bhn237
关键词
absence epilepsy; cortical inactivation; in vivo; somatosensory cortex; thalamus
资金
- Agence Nationale de la Recherche [ANR RO6275CS, 2006]
- Institut National de la Sante et de la Recherche Medicale
- Fondation Francxaise pour la Recherche sur l'Epilepsie
- Ligue Francxaise Contre l'Epilepsie
- Pfizer
Absence seizures consist of bilateral spike-and-wave discharges (SWDs) occurring over widespread cortical and thalamic regions. In genetic models of absence epilepsy, recent in vivo investigations indicate that SWDs emerge first in the facial somatosensory cortex and then propagate via the corticothalamocortical loop. The specific involvement of this cortical region in ictogenic processes remained to be established and the participation of its related thalamocortical system in seizure initiation remained unclear. Here, using electrocorticographic (ECoG) and intracellular recordings in vivo from cortex and thalamus in the Genetic Absence Epilepsy Rat from Strasbourg (GAERS), we obtained novel evidence for the cortical focus theory of absence epilepsy. We report that blockade of action potential discharge and synaptic activities in facial somatosensory cortical neurons, by topical application of tetrodotoxin, prevents the occurrence of paroxysmal activities in local and distant cortical neurons and ECoGs, as well as in thalamocortical neurons in register with the somatosensory cortex. In contrast, pharmacological inhibition of a remote motor cortical region or of the related thalamic nuclei did not suppress ictal activities in the somatosensory cortex. This study demonstrates that SWDs in GAERS have a focal origin within the facial somatosensory cortex, which is sufficient and necessary to generate ictal activities.
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