期刊
CEREBRAL CORTEX
卷 20, 期 8, 页码 1816-1828出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/cercor/bhp250
关键词
anterior cingulate; orbitofrontal cortex; prelimbic cortex; reversible inactivation; rat
资金
- Canadian Institutes of Health Research [MOP-89861]
- Natural Sciences and Engineering Research Council of Canada
- Michael Smith Foundation for Health Research
Damage to various regions of the prefrontal cortex (PFC) impairs decision making involving evaluations about risks and rewards. However, the specific contributions that different PFC subregions make to risk-based decision making are unclear. We investigated the effects of reversible inactivation of 4 subregions of the rat PFC (prelimbic medial PFC, orbitofrontal cortex [OFC], anterior cingulate, and insular cortex) on probabilistic (or risk) discounting. Rats were well trained to choose between either a Small/Certain lever that always delivered 1 food pellet, or another, Large/Risky lever, which delivered 4 pellets, but the probability of receiving reward decreased across 4 trial blocks (100%, 50%, 25%, and 12.5%). Infusions of gama-aminobutyric acid agonists muscimol/baclofen into the medial PFC increased risky choice. However, similar medial PFC inactivations decreased risky choice when the Large/Risky reward probability increased over a session. OFC inactivation increased response latencies in the latter trial blocks without affecting choice. Anterior cingulate or insular inactivations were without effect. The effects of prelimbic inactivations were not attributable to disruptions in response flexibility or judgments about the relative value of probabilistic rewards. Thus, the prelimbic, but not other PFC regions, plays a critical role in risk discounting, integrating information about changing reward probabilities to update value representations that facilitate efficient decision making.
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