期刊
CEREBRAL CORTEX
卷 19, 期 -, 页码 I96-I106出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/cercor/bhp045
关键词
CGE; Dlx; Mash; MGE; transcription factor
资金
- Larry L. Hillblom Foundation
- National Institute Of Mental Health [R01 MH49428-01, R37 MH49428-16AI, K05 MH065670, F32 MH070211]
- National Alliance for Research on Schizophrenia and Depression Young Investigator Award [MIRG-CT-2007-210080]
Here we define the expression of similar to 100 transcription factors (TFs) in progenitors and neurons of the developing mouse medial and caudal ganglionic eminences, anlage of the basal ganglia and pallial interneurons. We have begun to elucidate the transcriptional hierarchy of these genes with respect to the Dix homeodomain genes, which are essential for differentiation of most gamma-aminobutyric acidergic projection neurons of the basal ganglia. This analysis identified Dlx-dependent and Dlx-independent pathways. The Dlx-independent pathway depends in part on the function of the Mash1 basic helix-loop-helix (b-HLH) TF. These analyses define core transcriptional components that differentially specify the identity and differentiation of the globus pallidus, basal telencephalon, and pallial interneurons.
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