期刊
CEREBRAL CORTEX
卷 19, 期 4, 页码 832-838出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/cercor/bhn131
关键词
anterior temporal lobes; rTMS; semantic dementia; semantic memory
资金
- Research Councils UK [078734/Z/05/Z]
- Medical Research Council programme [G0501632]
- Wellcome Trust [078734/Z/05/Z] Funding Source: Wellcome Trust
- MRC [G0501632] Funding Source: UKRI
Conceptual knowledge provides the basis on which we bring meaning to our world. Studies of semantic dementia patients and some functional neuroimaging studies indicate that the anterior temporal lobes, bilaterally, are the core neural substrate for the formation of semantic representations. This hypothesis remains controversial, however, as traditional neurological models of comprehension do not posit a role for these regions. To adjudicate on this debate, we conducted 2 novel experiments that used off-line, low-frequency, repetitive transcranial magnetic stimulation to disrupt neural processing temporarily in the left or right temporal poles (TPs). The time required to make semantic decisions was slowed considerably, yet specifically, by this procedure. The results confirm that both TPs form a critical substrate within the neural network that supports conceptual knowledge.
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