期刊
CEREBRAL CORTEX
卷 19, 期 8, 页码 1787-1794出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/cercor/bhn209
关键词
autism; children; cognition; functional connectivity; response inhibition
资金
- Frederick and Elizabeth Singer Foundation
- Studies for the Advancement of Autism Research and Treatment [U54 MH066417]
- Intellectual and Developmental Disabilities Research Center at Children's National Medical Center [P30HD40677]
- General Clinic Research Center [M01-RR13297, T-32]
- NIH [T32HD046388]
Unmasking the neural basis of neurodevelopmental disorders, such as autism spectrum disorders (ASD), requires studying functional connectivity during childhood when cognitive skills develop. A functional connectivity magnetic resonance imaging (fcMRI) analysis was performed on data collected during Go/NoGo task performance from 24 children ages 8-12 years (12 with ASD; 12 controls matched on age and intellectual functioning). We investigated the connectivity of the left and right inferior frontal cortex (IFC; BA 47), key regions for response inhibition, with other active regions in frontal, striatal, and parietal cortex. Groups did not differ on behavioral measures or functional connectivity of either IFC region. A trend for reduced connectivity in the right IFC for the ASD group was revealed when controlling for age. In the ASD group, there was a significant negative correlation between age and 2 right IFC correlation pairs: right IFC-bilateral presupplementary motor area (BA 6) and right IFC-right caudate. Compared with typical controls, children with ASD may not have gross differences in IFC functional connectivity during response inhibition, which contrasts with an adult study of ASD that reported reduced functional connectivity. This discrepancy suggests an atypical developmental trajectory in ASD for right IFC connectivity with other neural regions supporting response inhibition.
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