期刊
CEREBRAL CORTEX
卷 19, 期 3, 页码 586-592出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/cercor/bhn111
关键词
Alzheimer's disease; confocal microscopy; dementia; dentate gyrus; transgenic mice
资金
- Fundacion Caixa [BM05-47-0]
- EU 6th Framework Program [LSHM-CT-2005-512012]
- Spanish Ministry of Science and Technology [BFU2006-13395]
- Ministry of Science and Technology
The mechanism by which dementia occurs in patients with Alzheimer's disease (AD) is not known. We assessed changes in hippocampal dendritic spines of APP/PS1 transgenic mice that accumulate amyloid beta throughout the brain. Three-dimensional analysis of 21 507 dendritic spines in the dentate gyrus, a region crucial for learning and memory, revealed a substantial decrease in the frequency of large spines in plaque-free regions of APP/PS1 mice. Plaque-related dendrites also show striking alterations in spine density and morphology. However, plaques occupy only 3.9% of the molecular layer volume. Because large spines are considered to be the physical traces of long-term memory, widespread decrease in the frequency of large spines likely contributes to the cognitive impairments observed in this AD model.
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