期刊
CANCER BIOLOGY & THERAPY
卷 1, 期 2, 页码 91-96出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/cbt.50
关键词
basic helix-loop-helix proteins; transcription factor; cell cycle; differentiation; tumorigenesis; oncogenes; Id proteins
类别
资金
- NCI NIH HHS [R01 CA81135, R01 CA66980] Funding Source: Medline
- NIDCR NIH HHS [P01 DE00275] Funding Source: Medline
The Id (Inhibitor of differentiation or Inhibitor of DNA-binding) proteins act as dominant negative inhibitors of differentiation-specific basic Helix-Loop-Helix (bHLH) transcription factors. Id proteins negatively regulate cellular differentiation and they induce proliferation by modulating different cell cycle regulators both by direct and indirect mechanisms. Ectopic expression of Id proteins in tissue culture models can result in cellular immortalization and abrogation of differentiation processes. Recent reports show that Id proteins are overexpressed in various cancer types implying a role of these regulatory proteins in carcinogenesis. This review focuses on the biology of the Id proteins and their role as potential oncogenes.
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