Changes in antioxidant status of lung tissue in experimental diabetes in rabbits

Objectives: Hyperglycaemia can result in oxidative stress which may affected as cellular tissue damage. Design and methods: After 3, 6, 12 and 24 weeks of hyperglycaemia oxidative stress related parameters were measured in lung tissue of diabetic and control rabbits. Results: Decreased activities of antioxidative compounds and intensification of lipid peroxidation process were found in diabetic lung. Conclusions: The data obtained suggest that hyperglycaemia induces oxidative stress in lung tissue which may play an important role in pathogenesis of diabetic complications. (C) 2002 The Canadian Society of Clinical Chemists. All rights reserved.