期刊
CEREBELLUM
卷 11, 期 3, 页码 777-807出版社
SPRINGER
DOI: 10.1007/s12311-012-0355-9
关键词
Cerebellum; Autism
资金
- Alfred and Ingrid Lenz Harrison Autism Initiative
- Autism Speaks Foundation
- Jane Botsford Johnson Foundation
- National Alliance for Research on Schizophrenia and Depression
- National Institute of Neurological Disorders and Stroke [R21HD065269]
- Peter Emch Foundation
- Nancy Lurie Marks Family Foundation
- NINDS [NS38975-05]
- NAAR/Autism Speaks
- Autism Speaks [4853]
- NIH/NINDS [R01 NS063009]
- Hussman Foundation
- Department of Defense [AS073224P2]
- Autism Research Institute
- Autism Collaboration (autism.org)
- NYS Office for People with Developmental Disabilities
- Autism Centers of Excellence [NICHD P50-HD055782]
- NICHD [HD35465 NICHD, RO1-HD055741]
- ACE Network (NICHD) [HD05571]
- American Recovery and Reinvestment Act [NICHD R01-HD065283]
- National Institute for Neurological Disorders and Stroke [NINDS R01-NS31224-18, R01 NS31224-18]
- Simons Foundation
- NIH [RO1NS060887, R01NS063009]
- Eunice Kennedy Shriver National Institute of Child Health & Human Development [P50 HD055782]
- Autism Center of Excellence from the Eunice Kennedy Shriver NICHD [P50HD055751]
- NIMH [1K23MH092696]
- Janssen Foundation
- Italian Ministry of University, Research and Technology [2006058195, 2008BACT54]
- Italian Ministry of Health [RFPS-2007-5-640174]
- Autism Research Institute (San Diego, CA)
- Autism Speaks (Princeton, NJ)
- Fondazione Gaetano e Mafalda Luce (Milan, Italy)
- Cure Autism now
- Eunice Kennedy Shriver National Institute of Child Health and Human Development [5R01HD052074-05, 3R01HD05207403-S1]
There has been significant advancement in various aspects of scientific knowledge concerning the role of cerebellum in the etiopathogenesis of autism. In the current consensus paper, we will observe the diversity of opinions regarding the involvement of this important site in the pathology of autism. Recent emergent findings in literature related to cerebellar involvement in autism are discussed, including: cerebellar pathology, cerebellar imaging and symptom expression in autism, cerebellar genetics, cerebellar immune function, oxidative stress and mitochondrial dysfunction, GABAergic and glutamatergic systems, cholinergic, dopaminergic, serotonergic, and oxytocin-related changes in autism, motor control and cognitive deficits, cerebellar coordination of movements and cognition, gene-environment interactions, therapeutics in autism, and relevant animal models of autism. Points of consensus include presence of abnormal cerebellar anatomy, abnormal neurotransmitter systems, oxidative stress, cerebellar motor and cognitive deficits, and neuroinflammation in subjects with autism. Undefined areas or areas requiring further investigation include lack of treatment options for core symptoms of autism, vermal hypoplasia, and other vermal abnormalities as a consistent feature of autism, mechanisms underlying cerebellar contributions to cognition, and unknown mechanisms underlying neuroinflammation.
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