期刊
CEREBELLUM
卷 8, 期 1, 页码 64-69出版社
SPRINGER
DOI: 10.1007/s12311-008-0075-3
关键词
GABBR1; GABBR2; Autism; Cerebellum; BA9; BA40
资金
- PHS [R24 MH068855]
- Brain Endowment Bank
- National Parkinson Foundation, Inc., Miami, FL, USA
- National Institute of Child Health and Human Development [5R01HD052074-01A2]
Autism is a neurodevelopmental disorder that is often comorbid with seizures. Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in brain. GABA(B) receptors play an important role in maintaining excitatory-inhibitory balance in brain and alterations may lead to seizures. We compared levels of GABA(B) receptor subunits GABA(B) receptor 1 (GABBR1) and GABA(B) receptor 2 (GABBR2) in cerebellum, Brodmann's area 9 (BA9), and BA40 of subjects with autism and matched controls. Levels of GABBR1 were significantly decreased in BA9, BA40, and cerebellum, while GABBR2 was significantly reduced in the cerebellum. The presence of seizure disorder did not have a significant impact on the observed reductions in GABA(B) receptor subunit expression. Decreases in GABA(B) receptor subunits may help explain the presence of seizures that are often comorbid with autism, as well as cognitive difficulties prevalent in autism.
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