期刊
JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY
卷 13, 期 1, 页码 19-35出版社
SOC BRASILEIRA QUIMICA
DOI: 10.1590/S0103-50532002000100004
关键词
oxidative stress; bioreductive alkylation; tropical diseases; quinones; nitroaromatics; N-oxides; electron transfer
This review summarises some of the more relevant achievements in the correlation between electrochemical processes and parameters and bioactive properties, mainly related to cancer and tropical diseases. Despite the broad range of possibilities and the complexity of cell/tissue/extracell chemistry, it is possible to rationalise the role of electrochemistry in few basic theoretical frameworks, mainly, the one based on electron transfer-oxidative stress and in situ generation of toxic species, other than the reactive oxygen species; interaction with endobiotics, with emphasis on bioreductive alkylation and replacement of endobiotics with function in biological redox reactions. The use of electrochemical methods to obtain relevant informations about drugs' mechanism of action and analysis of cellular events is also presented. Electrochemical methods and/or parameters play essential but not absolute roles.
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