期刊
JOURNAL OF HUMAN GENETICS
卷 47, 期 11, 页码 605-610出版社
SPRINGERNATURE
DOI: 10.1007/s100380200092
关键词
single-nucleotide polymorphism (SNP); Japanese population; genetic marker; association study; common diseases
To construct an infrastructure for genome-wide association studies of common diseases or drug sensitivities, we have been systematically exploring common variants by resequencing genomic regions containing genes in DNA from 24 Japanese individuals. We have analyzed a total of 154Mb, corresponding to approximately 5% of the human genome, and so far have identified 174269 single-nucleotide polymorphisms and 16293 insertion/deletion polymorphisms within gene regions, i.e., one polymorphism in 807 bp on average. Our data are freely available via our web site (http://snp.ims.u-tokyo.ac.jp) and will facilitate studies to identify genes associated with susceptibility to common diseases and genes involved in sensitivity to therapeutic drugs.
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