期刊
CEREBROVASCULAR DISEASES
卷 13, 期 -, 页码 42-47出版社
KARGER
DOI: 10.1159/000049149
关键词
amyloid; congophilic material; angiopathy; hereditary; beta-amyloid precursor protein; vascular dementia; stroke; transgenic mouse
资金
- NIA NIH HHS [AG00725] Funding Source: Medline
Cerebral amyloid angiopathy (CAA), defined by deposition of the beta-amyloid peptide in medium and small cortical and meningeal vessels, is a well-recognized cause of hemorrhagic stroke. This paper reviews the accumulating evidence supporting an additional role for CAA in producing vessel dysfunction, reduced cerebral blood flow and ischemia. Ischemic lesions are characteristic of several hereditary CAA syndromes, including a recently described mutation of the amyloid precursor protein associated with dementia (but not hemorrhagic stroke) in an Iowa family. Ischemic lesions are seen in some sporadic CAA patients as well, and recent data from transgenic mice suggest potential mechanisms by which beta-amyloid may alter vessel physiology. Future studies will seek to define the clinical importance of vascular beta-amyloid as a potential target for drug therapy in dementia. Copyright (C) 2002 S. KargerAG, Basel.
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