期刊
CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE
卷 5, 期 2, 页码 153-158出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00075197-200203000-00006
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资金
- NHLBI NIH HHS [HL40404] Funding Source: Medline
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL040404] Funding Source: NIH RePORTER
The acute phase reactions, associated with injury, inflammation, or sepsis, markedly affect the concentration and composition of plasma lipids and lipoproteins. Hepatic production of triglycerides and very low density lipoprotein formation are increased, but do not necessarily result in high plasma triglyceride levels. In contrast, all conditions lower plasma cholesterol by decreasing its content in both low-density and high-density lipoproteins. In addition, substantial changes in protein and lipid composition of lipoproteins are observed that may redefine the function of these particles, but also increase their atherogenic and inflammatory properties. (C) 2002 Lippincott Williams Wilkins.
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