期刊
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
卷 67, 期 1, 页码 39-54出版社
ELSEVIER SCI IRELAND LTD
DOI: 10.1016/S0169-2607(00)00146-2
关键词
convection-diffusion-permeation-reaction modeling; numerical solutions to partial differential equations; water transport in heart; blood-tissue exchange kinetics; erythrocyte precession; oxygen metabolism; positron emission tomography
类别
资金
- NATIONAL CENTER FOR RESEARCH RESOURCES [P41RR001243] Funding Source: NIH RePORTER
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [P01HL038736, T32HL007403] Funding Source: NIH RePORTER
- NCRR NIH HHS [RR1243, P41 RR001243-210021] Funding Source: Medline
- NHLBI NIH HHS [T32 HL07403, HL38736, T32 HL007403] Funding Source: Medline
A computational model of oxygen transport from red blood cells to mitochondria with subsequent reaction to water is presented. This computational model consists of a five region convection-diffusion-reaction mathematical model which is solved using a standard numerical time-split method. The unique feature of this mathematical model is the treatment of the red blood cells and the plasma as two separate flows. The numerical method is second order accurate overall. This computational model is useful for analyzing residue data from positron emission tomography or data from multiple indicator dilution curves. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
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