期刊
CHRONOBIOLOGY INTERNATIONAL
卷 19, 期 4, 页码 721-730出版社
TAYLOR & FRANCIS INC
DOI: 10.1081/CBI-120005394
关键词
body temperature; menstrual cycle; progesterone; prostaglandin inhibitors
An investigation into whether the rise in the 24h body temperature rhythm observed in the luteal menstrual phase is antagonized by the administration of prostaglandin synthesis inhibitors has been made. Intravaginal body temperature was monitored continuously for 24h, once in the follicular and twice in the luteal phase. In the luteal phase, women were studied both without and with the simultaneous administration of a prostaglandin synthesis inhibitor (lysine acetylsalicylate; 1.8 g every 6h orally). The progesterone/estradiol ratio (measured at 17:00h each day) was related to mesor (r=0.825; P<0.001), acrophase (r=0.682; P<0.02), and amplitude (r=-0.731; P<0.001) of the 24h body temperature rhythm. Luteal phase elevation of the progesterone/estradiol ratio was associated with a 0.32 +/- 0.07degreesC increase in mesor (P<0.01), a 0.11 +/- 0.02degreesC decrease in amplitude (P<0.001), and a 34.8 +/- 11.6 min delay in acrophase (P<0.03) of the 24h body temperature rhythm. Prostaglandin synthesis inhibitors did not counteract these modifications. The present data shows that the modifications of the circadian parameters of the 24h body temperature rhythm observed during the luteal phase of the menstrual cycle are strictly related to modifications of the progesterone/estradiol ratio, and presumably independent of prostaglandin synthesis.
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