期刊
CERAMICS INTERNATIONAL
卷 40, 期 7, 页码 10831-10838出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.ceramint.2014.03.075
关键词
Hydroxyapatite; Chemical precipitation; Antimicrobial study; Silver; TEM
资金
- CSIR-CECRI [MLP0053]
- Department of Science and Technology, India [GAP 11/13]
In the present study, the pH dependence hydroxyapatite (HAp) ceramics synthesis, and, their phase stabilities with respect to calcination temperatures were examined. Subsequently, HAp ceramics mixed with different silver amounts (HAp-Ag composites) were prepared in the temperature range 800-1200 degrees C to evaluate the phase stability of HAp in presence of silver. XRD results showed that as-synthesized HAp powder to be partially crystalline and are independent of pH of solution in the range of 9-11. These HAp phases remained stable even upto 1200 degrees C although crystallinity increased in all cases. Additional Ag peaks were appeared in HAp Ag composites when the mixed powders were heated in the temperature range 800-1200 degrees C. FTIR result further confirmed the presence of Ca2+ and PO43- ions. TEM observation showed the precipitation of needle like HAp nanocrystals of 20-40 nm in length which agglomerated into particulate morphology above 800 degrees C. Antibacterial study of HAp Ag composites on Staphylococcus aureus for 1, 3 and 5 wt% silver concentration showed that 3 wt% silver is sufficient to kill the surrounding bacteria. Further studies on NIH3T3 cells for HAp Ag composites at 10 wt% silver of different concentrations showed good cytocompatibility compared to HAp indicates the prospective applications in therapeutic interventions. (C) 2014 Elsevier Ltd and Techna Group S.r.l. All rights reserved.
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