期刊
CERAMICS INTERNATIONAL
卷 40, 期 9, 页码 13987-13993出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.ceramint.2014.05.123
关键词
Calcium phosphate cement; Complex; Hydroxyapatite; Mechanical reinforcement; Silk fibroin
资金
- National Natural Science Foundation of China [81171479]
- Natural Science Foundation of Jiangsu Province [BK2011291]
- Jiangsu Provincial Special Program of Medical Science [BL2012004]
Calcium phosphate cements (CFCs) are promising injectable orthopedic materials with excellent biocompatibility and osteoconductivity. However, the inferior mechanical strength limits their use to low load-bearing areas only. In this study, we synthesized hydroxyapatite (HA)-silk fibroin (SF) complex through a co-precipitation method and supplemented it to an injectable CPC/SF composite. We found that the compressive strength of the three-component composite, CPC/HA-SF/SF, kept increasing with HA-SF content if it did not exceed 3 wt%. Such a reinforcing effect was likely the result of improved interfacial integrity and oriented growth of HA crystals in CPC/SF composite upon HA-SF supplementation. The setting time of CPC/HA-SF/SF composites decreased as a function of HA-SF content, with no apparent effect on injectability. Moreover, the CPC/HA-SF/SF composites showed good biocompatibility both in vitro and in vivo. Such composites hold good promise for many orthopedic applications, including serving as filler materials for minimally invasive surgeries to treat vertebral fractures. (C) 2014 Elsevier Ltd and Techna Group S.r.l. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据