期刊
CERAMICS INTERNATIONAL
卷 40, 期 4, 页码 5481-5488出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.ceramint.2013.10.136
关键词
TiO2-PEG-folic acid; Photocatalytic activity; Doxorubicin; Cytotoxicity; MTT assay
TiO2 nanoparticles (NPs) were synthesized by hydrothermal assisted sol gel technique. In the next step, as-synthesized NPs were modified by poly ethylene glycol (PEG). Then, folic acid (PA) was conjugated to TiO2-PEG. Finally, Doxorubicin (Dox) as an anticancer drug was loaded on as-prepared TiO2-PEG-FA nanocarrier. The optimization of TiO2 and FA concentration and the influence of ultraviolet (UV) irradiation on photocatalytic activity of nanocarrier and Dox loaded carrier were assessed by utilizing the 3-(4,5-dimethylthiazol-2yl)-2,5-diphenyltetrazolium bromide (MTT)-assay method. Results indicated that the effect of NPs on cancer cells killing is dose-dependent, optimized at 1.25 g/L. The performance of FA on the selective targeting was confirmed and maximized at FA/TiO2=0.5. As-optimized TiO2-PEG-FA Dox conjugate, in comparison to pure Dox, was more effective as far as cancer cell viability reduced to about 5%, especially under UV irradiation. (C) 2013 Elsevier Ltd and Techna Group S.r.l. All rights reserved.
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