期刊
JOURNAL OF PINEAL RESEARCH
卷 32, 期 1, 页码 59-62出版社
BLACKWELL MUNKSGAARD
DOI: 10.1034/j.1600-079x.2002.00841.x
关键词
Alzheimer's disease; hippocampus; immunohistochemistry; melatonin 1a-receptor (MT1)
The pineal secretory product melatonin has, in addition to regulating retinal, circadian and vascular functions, neuroprotective effects. Blood melatonin levels are often decreased in Alzheimer's disease (AD), a progressively disabling neurodegenerative disorder. In this study we provide the first immunohistochemical evidence for the localization of melatonin la-receptor (MT1) in aged human hippocampus and a comparison of AD cases. MT1 was localized to pyramidal neurons in the hippocampal cornu ammonis (CA) 1-4 subfields. There was a distinct increase in staining intensity in all AD cases indicating an up-regulation of the receptor, possibly as a compensatory response to impaired melatonin levels in order to augment melatonin's neuroprotective effects.
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