期刊
HIPPOCAMPUS
卷 12, 期 3, 页码 291-303出版社
WILEY
DOI: 10.1002/hipo.1112
关键词
place cell; head direction cell; theta cell; spatial memory; vestibular system; navigation
资金
- NATIONAL INSTITUTE OF MENTAL HEALTH [K02MH001286, R01MH048924, R29MH048924] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS [F32DC000236] Funding Source: NIH RePORTER
- NIDCD NIH HHS [DC00236, F32 DC000236, R01 DC000236] Funding Source: Medline
- NIMH NIH HHS [R29 MH048924, R01 MH048924, K02 MH001286, MH01286, MH48924] Funding Source: Medline
The hippocampal formation is essential for forming declarative representations of the relationships among multiple stimuli. The rodent hippocampal formation, including the entorhinal cortex and subicular complex, is critical for spatial memory. Two classes of hippocampal neurons fire in relation to spatial features. Place cells collectively map spatial locations, with each cell firing only when the animal occupies that cell's place field, a particular subregion of the larger environment. Head direction (HD) cells encode directional heading, with each HD cell firing when the rat's head is oriented in that cell's particular preferred firing direction. Both landmarks and internal cues (e.g., vestibular, motor efference copy) influence place and HD cell activity. However, as is the case for navigation, landmarks are believed to exert greater influence over place and HD cell activity. Here we show that temporary inactivation of the vestibular system led to the disruption of location-specific firing in hippocampal place cells and direction-specific discharge of postsubicular HD cells, without altering motor function. Place and HD cell activity recovered over a time course similar to that of the restoration of vestibular function. These results indicate that vestibular signals provide an important influence over the expression of hippocampal spatial representations, and may explain the navigational deficits of humans with vestibular dysfunction.
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