期刊
CELL TRANSPLANTATION
卷 11, 期 7, 页码 621-630出版社
SAGE PUBLICATIONS INC
DOI: 10.3727/000000002783985404
关键词
anoikis; cell transplantation; hepatocytes; apoptosis; transplantation
Cell therapy, in particular liver cell transplantation, holds great therapeutic potential and is partially hindered by the high rate of apoptosis during cell isolation, cryopreservation, and engraftment. Apoptosis occurring due to cell detachment from the extracellular matrix is a phenomenon termed anoikis. The purpose of this review is to describe signaling mechanisms pertinent to anoikis in both immortalized cell lines, but particularly in primary normal epithelial cells. The mechanisms described include integrin signaling and survival molecules, caspase activation, and the role of mitochondrial proteins in anoikis. Strategies to prevent anoikis during isolation and cryopreservation of hepatocytes are discussed.
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