期刊
CERAMICS INTERNATIONAL
卷 39, 期 1, 页码 183-195出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.ceramint.2012.06.008
关键词
Mg alloys; Poly (lactic acid); Orthopedic applications; Biodegradable implants
资金
- Chonbuk National University
The corrosion behavior of magnesium and its alloys in the electrolytic physiological environment is extremely poor; this imposes a limitation for their use in orthopedic applications. In the present study, the effect of spray coating AZ31 magnesium alloy with membrane films of pristine and hydroxyapatite-doped poly(lactic acid) on corrosion behavior and bioactivity is investigated. Polymer concentration was found to have a strong impact on the pore size of the coating layer. However, addition of HAp NPs distinctly stimulated the precipitation of an apatite-like compound upon soaking the samples in a simulated body fluid (SBF). Magnesium coated samples revealed three orders of magnitude less corrosion compared to the naked samples, which indicates a stable electrochemical corrosion resistance. During a 15 days in-vitro test, pH variation, weight loss, and bending strength were lower for the coated samples (with average values of 8.5%, 7.2% and 10%, respectively) than the control sample (10.5%, 15.5%, and 25%, respectively). Moreover, the coated samples showed good bending strength characteristics. Cytocompatibility studies on MC3T3 cells revealed a continuous increase in cell growth with the coated samples. Overall, the suggested strategy might open a new avenue to widen utilization of Mg alloys as implant materials for orthopedic applications. (C) 2012 Elsevier Ltd and Techna Group S.r.l. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据