期刊
NEUROEPIDEMIOLOGY
卷 21, 期 2, 页码 58-67出版社
KARGER
DOI: 10.1159/000048618
关键词
olfaction; cognition; aging
资金
- NATIONAL INSTITUTE ON AGING [R01AG009341] Funding Source: NIH RePORTER
In 1992, the twelve-item Brief Smell Identification Test(R) and, in 1992 and 1996, a variety of measures of verbal learning and memory, executive control, and global function were administered to a total of 359 individuals (286 men and 73 women; mean age in 1992 74.3 years). Individuals with a history of stroke or impaired cognition at baseline were excluded from analyses. Impaired olfactory function (present or absent) was related to a greater 4.5-year decline on several indices of verbal memory, but not to a decline on measures of executive control or of global functioning after adjustment for baseline cognitive performance, age, education, gender, and history of smell difficulties. Olfactory loss remained associated with a decline in components of verbal memory, independently of the apolipoprotein E F,4 status. The predictive utility of impaired smell identification in older adults appears to be specific to a decline in components of verbal memory. Copyright (C) 2002 S. Karger AG, Basel.
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