期刊
TOXICOLOGY AND INDUSTRIAL HEALTH
卷 18, 期 7, 页码 309-320出版社
SAGE PUBLICATIONS INC
DOI: 10.1191/0748233702th157oa
关键词
inflammation; metal; neurodegenerative disease; neurotoxicology; oxidative stress
资金
- NIA NIH HHS [AG-16794] Funding Source: Medline
- NIEHS NIH HHS [ES 7992] Funding Source: Medline
- NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES [R01ES007992] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [R01AG016794] Funding Source: NIH RePORTER
Although aluminum is the most abundant metal in nature, it has no known biological function. However, it is known that there is a causal role for aluminum in dialysis encephalopathy, microcytic anemia, and osteomalacia. Aluminum has also been proposed to play a role in the pathogenesis of Alzheimer's disease (AD) even though this issue is controversial. The exact mechanism of aluminum toxicity is not known but accumulating evidence suggests that the metal can potentiate oxidative and inflammatory events, eventually leading to tissue damage. This review encompasses the general toxicology of aluminum with emphasis on the potential mechanisms by which it may accelerate the progression of chronic age-related neurodegenerative disorders.
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