期刊
GLYCOCONJUGATE JOURNAL
卷 19, 期 7-9, 页码 459-465出版社
SPRINGER
DOI: 10.1023/B:GLYC.0000014075.62724.d0
关键词
galectin-1; galectin-3; galectin-7; thermodynamics; binding specificity
资金
- NCI NIH HHS [P30 CA-13330, CA-16054] Funding Source: Medline
- NATIONAL CANCER INSTITUTE [R01CA016054, P30CA013330] Funding Source: NIH RePORTER
The carbohydrate binding specificities of the galectin family of animal lectins has been the source of intense recent investigations. Isothermal titration microcalorimetry (ITC) provides direct determination of the thermodynamics of binding of carbohydrates to lectins, and has provided important insights into the fine carbohydrate binding specificities of a wide number of plant and animal lectins. Recent ITC studies have been performed with galectin-1, galectin-3 and galectin-7 and their interactions with sialylated and non-sialylated carbohydrates. The results show important differences in the specificities of these three galectins toward poly-N-acetyllactosamine epitopes found on the surface of cells.
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