Pramipexole ameliorates neurologic and psychiatric symptoms in a Westphal variant of Huntington's disease

Levodopa is recommended as a therapeutic approach for patients with the hypokinetic-rigid. Westphal variant of Huntington's disease, but no guidelines are available for the case of nonrespondence to levodopa. In this study, however, we report a 34-year-old woman with this rare variant who showed a clear-cut improvement in motor function and depressive symptoms after treatment with pramipexole, a new dopamine agonist.