期刊
BIOGERONTOLOGY
卷 3, 期 1-2, 页码 89-94出版社
KLUWER ACADEMIC PUBL
DOI: 10.1023/A:1015223917491
关键词
aging; DNA metabolism; DNA repair; Werner syndrome
资金
- NATIONAL INSTITUTE ON AGING [ZIAAG000726, Z01AG000726] Funding Source: NIH RePORTER
Werner syndrome is the hallmark premature aging disease, where the patients appear much older than their chronological age. The Werner protein, defective in this disorder, is a DNA helicase and an exonuclease, and it participates in pathways of DNA repair, recombination, transcription and replication. The function and role of this protein is discussed in the light of how it functions in the aging process.
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