期刊
BIOGERONTOLOGY
卷 3, 期 5, 页码 307-315出版社
SPRINGER
DOI: 10.1023/A:1020155502734
关键词
aging; exclusion; insoluble protein; polypeptide net work
It is proposed that biological aging mainly depends on a deleterious accumulation of insoluble inert protein that has escaped physiological proteolytic degradation. Intracellularly, a three-dimensional network of polypeptide chains may exclude macromolecular structures and organelles from part of the cytosolic water. In this way vital intracellular transport mechanisms may be obstructed, providing a rationale to several observations linked to aging.
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