期刊
JOURNAL OF BONE AND MINERAL METABOLISM
卷 20, 期 4, 页码 216-222出版社
SPRINGER JAPAN KK
DOI: 10.1007/s007740200031
关键词
vitamin K-2; microgravity; tail suspension; bone volume; trabecular structure
Bone volume loss is one of the major health problems during long-term spaceflight. We examined the effects of vitamin K-2 on bone abnormalities in tail-suspended mature male Sprague-Dawley rats (13 weeks old). In this model, increased bone resorption and sustained suppression of bone formation resulted in progressive bone loss in 4 weeks, which simulates bone changes in humans during spaceflight. A significant decrease in bone mineral density (BMD), as well as a decreased mineral apposition rate (MAR), increased number of osteoclasts per bone perimeter (N.Oc/B.Pm), and increased osteoclast surface per bone surface (Oc.S/BS) in the suspended group was effectively prevented by vitamin K-2 given orally (menatetrenone, 22mg/kg body weight). Microfocus computed tomography (CT) and node-strut analyses revealed that the volume and structure of trabecular bone were maintained near normal by the vitamin K-2 treatment. A recent report has suggested the abnormal metabolism or action of vitamin K in a microgravity environment, and our data therefore suggest that vitamin K-2 may be useful for the prevention of bone loss and for the maintenance of normal trabecular structure during spaceflight.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据