期刊
IMMUNOLOGIC RESEARCH
卷 26, 期 1-3, 页码 309-321出版社
HUMANA PRESS INC
DOI: 10.1385/IR:26:1-3:309
关键词
T cells; viral infection; tetramers; cytokines; persistence
类别
资金
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R56AI049360, R01AI049360] Funding Source: NIH RePORTER
- NIAID NIH HHS [AI49360] Funding Source: Medline
The elaboration of a successful immune response is critical for the clearance of viral infections. CD8 T cells can directly kill virus-infected cells and also produce cytokines that modulate virus replication. Thus, the failure to induce or sustain these responses can profoundly impact the outcome of infections. Lymphocytic choriomeningitis virus (LCMV) infection of mice has proven to be one of the most informative experimental systems for examining antiviral T cell responses. In recent years, the application of newly developed approaches to analyze these responses has revealed that acute infections induce remarkably high levels of antiviral T cells. By contrast, protracted or chronic infections are associated with both the functional impairment and deletion of virus-specific CD8 T cells. This article discusses some of our findings using LCMV infection of mice as well as their relevance to other infections of animals and humans.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据