期刊
VIRAL IMMUNOLOGY
卷 15, 期 4, 页码 609-625出版社
MARY ANN LIEBERT, INC
DOI: 10.1089/088282402320914548
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资金
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI036418, P01AI039808, R01AI045059] Funding Source: NIH RePORTER
- NIAID NIH HHS [AI39808, AI45059, AI36418] Funding Source: Medline
Two clinical syndromes are associated with hantavirus infection in humans: hemorrhagic fever with renal syndrome (HFRS) and hantavirus pulmonary syndrome (HPS). Autopsy findings typically reveal a common feature of increased permeability in microvascular beds, suggesting vascular endothelium is a prime target for virus infection. Endothelial cells are susceptible to hantavirus infection; however, virus does not cause cytopathic effects, to explain increased endothelium permeability. Therefore, immune mechanisms were suggested to play a crucial role in hantavirus pathogenesis. In this review, we summarize data on hantavirus-induced immune disturbances and discuss their implication in capillary leakage caused by hantavirus infection.
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