期刊
BREAST CANCER RESEARCH
卷 4, 期 6, 页码 231-239出版社
BMC
DOI: 10.1186/bcr535
关键词
breast cancer; insulin-like growth factor; insulin-like growth factor binding proteins; mammary gland
类别
Insulin-like growth factor (IGF)-mediated proliferation and survival are essential for normal development in the mammary gland during puberty and pregnancy. IGFs interact with IGF-binding proteins and regulate their function. The present review focuses on the role of IGFs and IGF-binding proteins in the mammary gland and describes how modulation of their actions occurs by association with hormones, other growth factors and the extracellular matrix. The review will also highlight the involvement of the IGF axis in breast cancer.
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